Tuesday, January 31, 2012

Emboldened GOP wants to abolish state income taxes (AP)

OKLAHOMA CITY ? A year after Republicans swept into office across the country, many have trained their sights on what has long been a fiscal conservative's dream: the steep reduction or even outright elimination of state income taxes.

The idea has circulated among academics and think-tank researchers for years. But it's moving quietly into mainstream political discourse, despite the fact that such sweeping changes would almost certainly mean a total rewiring of tax systems at a time when most states are still struggling in the aftermath of the recession.

"I think there's going to be more action that way," especially as Republican governors release their budget plans, said Kim Rueben, an expert on state taxation at the Brookings Urban Tax Policy Center.

Last year, GOP lawmakers in many states quickly went to work on a new conservative agenda: restricting abortion, cracking down on illegal immigration, expanding gun rights and taking aim at public-employee unions.

Emboldened by that success, the party has launched income tax efforts in Idaho, Kansas, Maine, Missouri, Ohio, Oklahoma and South Carolina. But it's not clear how all those states would make up for the lost revenue, and Rueben said she's not aware of any state in modern history that has eliminated an income tax.

Nine states already get by without an income tax, mostly by tapping other sources of revenue. Nevada and Florida rely on sales taxes that target the tourism industry. Alaska has taxes on natural resources, and Texas imposes substantial property taxes. The other five states are: New Hampshire, South Dakota, Tennessee, Washington and Wyoming.

But in the rest of the country, income taxes pay for bedrock government services, including roads and bridges and schools and prison systems.

In Oklahoma, Republican Gov. Mary Fallin says gradually cutting the top income-tax rate of 5.25 percent will make the state more attractive to businesses, help spur economic growth and ensure Oklahoma is competitive against neighboring states such as Texas. Although the personal income tax does not apply to corporate earnings, supporters say company executives and employees will prefer to live in a state that doesn't tax personal income.

South Carolina Gov. Nikki Haley is pushing this year to consolidate four personal income tax brackets and to phase out corporate income taxes. She promises to seek more tax cuts in the future.

Missouri has a bill to reduce income taxes and offset the lost revenue by raising the cigarette tax.

And Maine's GOP-controlled Legislature voted last year to lower the income tax from 8.5 to 7.95 percent, taking 70,000 low-income citizens off the income-tax rolls.

Idaho Gov. C.L. "Butch" Otter has suggested reducing the individual income tax rate from 7.8 percent to 7.6 percent, the same as the corporate income tax rate, and then gradually lowering both to 7 percent. But business groups have said they would rather get help eliminating the personal property tax businesses pay on their equipment.

In Ohio, Gov. John Kasich's 2010 campaign included a pledge to phase out the state's personal income tax, though without a timetable for doing so. Thus far, the state's fiscal situation has stymied the governor's efforts to achieve his goal, other than implementing a previously scheduled income tax cut.

As one way to compensate for the lost revenue, the Oklahoma governor and others have suggested eliminating other kinds of tax breaks and incentives, specifically transferrable tax credits offered to certain businesses. But that would still fall woefully short in Oklahoma, where the income tax provides more than one-third of all state spending.

Still, 23 Republicans in the Oklahoma House have signed up as sponsors of a measure to abolish the income tax over the next decade without raising any other taxes.

"Our goal is to transform Oklahoma into the best place to do business, the best place to live, find a quality job, raise a family and retire in all of the United States. Not just better than average, but the very best," state Rep. Leslie Osborn said.

Lower taxes appeal to many voters, but some wonder how the state could get by if lawmakers abandon a major source of money.

"I personally would favor paying less taxes, but to me, it's like where are we going to make up the difference?" said Steve Schlegel, a bicycle shop owner in Oklahoma City. "I already feel like government is underfunded at the moment."

Roger Garner, a letter courier, said he would accept higher property taxes if it meant eliminating the income tax.

"Get rid of it," Garner said. "Florida doesn't have it. Texas doesn't have it. We don't need it. If something is needed, we can figure out a way to pay for it at the local level."

Conservatives say the lost revenue will be made up by increased economic activity ? more businesses paying corporate taxes and more employees paying property taxes and spending money. But economists warn those predictions are unrealistic.

Without creating an alternative funding system, "it's clearly irresponsible to propose taking action against the income tax," said Alan Viard, an economist with the American Enterprise Institute, a Washington, D.C.-based conservative think tank.

Former Oklahoma Treasurer Scott Meacham, a Democrat who helped negotiate a series of small income tax cuts, urged state leaders to be careful tinkering with the state's economy, which is currently enjoying double-digit revenue growth and has one of the 10 lowest unemployment rates in the country.

"If you look at our state's economy, it's doing very well versus virtually any other state, whether they have a state income tax or not," said Meacham, who is now a member of the board of directors for the State Chamber, an association of Oklahoma business and industry.

Voters, he added, "ought to be very concerned, especially in an election year, when the politicians are telling them they know what's best for them from an economic standpoint."

In neighboring Kansas, Republican Gov. Sam Brownback has a sweeping plan to overhaul income taxes that calls for offsetting income tax cuts by canceling a scheduled drop in the sales tax. But it would increase the tax burden for the state's poorest households. And he faces resistance from within his own party over concern that the sales tax increase was supposed to be a temporary fix back in 2010.

A similar debate is unfolding in Oklahoma, where the plan calls for reducing the income tax from 5.25 percent to 4.75 percent by eliminating the personal exemption for every household member, including children, as well as the child tax credit and earned income tax credit.

An analysis by the Oklahoma Policy Institute shows those steps would raise taxes for 55 percent of Oklahomans, mostly low-income families and those with children.

"We have grave doubts about this proposal," said David Blatt, director of the institute. "We see stumbling blocks in every direction. You either decimate state services or shift the burden onto those that can least afford it."

___

Associated Press writers John Hanna in Topeka, Kan.; Seanna Adcox in Columbia, S.C.; David Lieb in Jefferson City, Mo.; and Glenn Adams in Augusta, Maine; Julie Carr Smyth in Columbus, Ohio; and John Miller in Boise, Idaho, contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ap/20120130/ap_on_bi_ge/us_eliminating_income_taxes

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Stealthy leprosy pathogen evades critical vitamin D-dependent immune response

ScienceDaily (Jan. 29, 2012) ? A team of UCLA scientists has found that the pathogen that causes leprosy has a remarkable ability to avoid the human immune system by inhibiting the antimicrobial responses important to our defenses.

In one of the first laboratory studies of its kind, researchers discovered that the leprosy pathogen Mycobacterium leprae was able to reduce and evade immune activity that is dependent on vitamin D, a natural hormone that plays an essential role in the body's fight against infections.

The pathogen manipulated micro-RNAs, tiny molecules made of ribonucleic acids that carry information and that help regulate genes to direct cell activity, including immune system defenses. Micro-RNAs are short RNAs that do not code information for proteins, which carry out all cell activity; rather, they bind to the RNAs that do code for proteins and block them.

Published in the Jan. 29 online edition of the journal Nature Medicine, the findings demonstrate how an infectious disease pathogen like M. leprae can use micro-RNAs to impact the immune system's fight response.

"We may find that these tiny micro-RNAs can be exploited by pathogens to weaken our immune response," said the study's first author, Dr. Philip T. Liu, an assistant professor of medicine at the Orthopaedic Hospital Research Center and in the department of dermatology at the David Geffen School of Medicine at UCLA. "By better understanding how pathogens can escape our immune cells, we can design more effective therapies to boost our immune responses to these difficult to treat infections like leprosy."

Leprosy, one of the world's oldest known diseases, is a chronic infectious disease that affects the skin, the peripheral nerves, the upper respiratory tract and the eyes and can lead to disfigurement of the hands, face and feet. In 2008, approximately 249,000 new cases of leprosy were reported worldwide, according to the World Health Organization.

For the study, researchers compared the micro-RNAs in human skin lesions from two types of leprosy: tuberloid leprosy, a milder infection that is more easily contained, and lepromatous leprosy, which is more serious and causes widespread infection throughout the body.

In the lab, the scientists identified 13 micro-RNAs that differed between the two types of leprosy. The micro-RNAs that were found to be more common in lepromatous leprosy seemed to target the genes important for directing key immune system cells, including macrophages and T cells.

The team found that a particular micro-RNA, hsa-mir-21, inhibited the gene activity of the vitamin D-dependent immune pathway used to help fight infection. When researchers neutralized the activity of hsa-mir-21 in macrophages, the cells were able to kill the bacteria again.

"The leprosy pathogen was able to effectively evade the host's immune response by regulating critical immune system genes," said senior investigator Dr. Robert Modlin, UCLA's Klein Professor of Dermatology and chief of dermatology at the Geffen School of Medicine. "It's like having the enemy sending a decoy message to your combat troops and telling them to lower their weapons."

To test the significance of this micro-RNA with other infectious diseases, the researchers also introduced hsa-mir-21 to human macrophages that were then infected with tuberculosis in the lab. Researchers found that the micro-RNA similarly blocked the ability of the macrophages to kill the bacteria.

Researchers also demonstrated that immune activation of the leprosy-infected immune cells decreased the leprosy bacteria's viability four-fold -- but only when hsa-mir-21 activity was silenced. In fact, an over-expression of this micro-RNA blocked immune activity, resulting in a five-fold increase in bacterial viability.

"We were surprised at the devastating effects that even a single micro-RNA had on the ability of immune cells to fight the infections," Liu said.

In addition, the team showed that this micro-RNA was found in human immune cells only 18 hours after the onset of leprosy infection. The presence of the micro-RNA so early in the infection suggests it might play a role in actual disease development, the researchers said.

Further investigation of this single micro-RNA in leprosy may provide a framework for analyzing other micro-RNAs to help determine their cumulative role in regulating the immune response.

The micro-RNAs are small, and therefore it is possible to develop treatments which neutralize them, the researchers said.

"We may find that a combination of vitamin D supplementation with a genetically targeted therapy could provide an optimal treatment approach to leprosy and possibly other chronic infectious diseases," said Modlin, who also serves as vice chair for cutaneous medicine and dermatological research at UCLA and is a distinguished professor of medicine and of microbiology, immunology and molecular genetics.

"Vitamin D insufficiency has been associated with a number of infectious and autoimmune diseases, cardiovascular disease and cancers," Modlin added. "Our study indicates that micro-RNAs can alter human vitamin D responses and contribute to disease pathology."

Dr. Barry Bloom of Harvard University, who was not an author of this study but is part of the research team studying this field, agreed.

"Such a novel approach may be especially worth exploring in treatment of drug-resistant pathogens such as some forms of tuberculosis, where antimicrobial therapy is becoming increasingly problematic," Bloom said.

Bloom, the former dean of the faculty at Harvard's School of Public Health, is Harvard's Distinguished University Service Professor and the Jack and Joan Jacobson Professor of Public Health in the School of Public Health's department of immunology and infectious diseases and department of global health and population.

The study was funded by the National Institute of Allergy and Infectious Diseases and the National Institute of Arthritis, Skin and Musculoskeletal Diseases, both parts of the National Institutes of Health.

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The above story is reprinted from materials provided by University of California, Los Angeles. The original article was written by Rachel Champeau.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Philip T Liu, Matthew Wheelwright, Rosane Teles, Evangelia Komisopoulou, Kristina Edfeldt, Benjamin Ferguson, Manali D Mehta, Aria Vazirnia, Thomas H Rea, Euzenir N Sarno, Thomas G Graeber, Robert L Modlin. MicroRNA-21 targets the vitamin D?dependent antimicrobial pathway in leprosy. Nature Medicine, 2012; DOI: 10.1038/nm.2584

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/5r_eln-mki8/120129151106.htm

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Monday, January 30, 2012

Ancient Mummy Had Prostate Cancer

CAIRO -- A professor from American University in Cairo says discovery of prostate cancer in a 2,200-year-old mummy indicates the disease was caused by genetics, not environment.

The genetics-environment question is key to understanding cancer.

AUC professor Salima Ikram, a member of the team that studied the mummy in Portugal for two years, said Sunday the mummy was of a man who died in his forties.

She said this was the second oldest known case of prostate cancer.

"Living conditions in ancient times were very different; there were no pollutants or modified foods, which leads us to believe that the disease is not necessarily only linked to industrial factors," she said.

A statement from AUC says the oldest known case came from a 2,700 year-old skeleton of a king in Russia.

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Source: http://www.huffingtonpost.com/2012/01/30/researchers-find-cancer-in-mummy_n_1240756.html

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EU leaders to agree on permanent bailout fund, balanced budget (Reuters)

BRUSSELS (Reuters) ? EU leaders will sign off on a permanent rescue fund for the euro zone at a summit on Monday and are expected to agree on a balanced budget rule in national legislation, with unresolved problems in Greece casting a shadow on the discussions.

The summit - the 17th in two years as the EU battles to resolve its sovereign debt problems - is supposed to focus on creating jobs and growth, with leaders looking to shift the narrative away from politically unpopular budget austerity.

The summit is expected to announce that up to 20 billion euros ($26.4 billion) of unused funds from the EU's 2007-2013 budget will be redirected toward job creation, especially among the young, and will commit to freeing up bank lending to small- and medium-sized companies.

But discussions over the permanent rescue fund, a new 'fiscal treaty' and Greece will dominate the talks.

Negotiations between the Greek government and private bondholders over the restructuring of 200 billion euros of Greek debt made progress over the weekend, but are not expected to conclude before the summit begins at 9:00 a.m. EST.

Until there is a deal between Greece and its private bondholders, EU leaders cannot move forward with a second, 130 billion euro rescue program for Athens, which they originally agreed to at a summit last October.

Instead, they will sign a treaty creating the European Stability Mechanism (ESM), a 500-billion-euro permanent bailout fund that is due to become operational in July, a year earlier than first planned. And they are likely to agree the terms of a 'fiscal treaty' tightening budget rules for those that sign up.

PERMANENT RESCUE FUND

The ESM will replace the European Financial Stability Facility (EFSF), a temporary fund that has been used to bail out Ireland and Portugal and will help in the second Greek package.

Leaders hope the ESM will boost defenses against the debt crisis, but many - including Italian premier Mario Monti, IMF chief Christine Lagarde and U.S. Treasury Secretary Timothy Geithner - say it will only do so if its resources are combined with what remains in the EFSF, creating a super-fund of 750 billion euros ($1 trillion).

The International Monetary Fund says an agreement to increase the size of the euro zone 'firewall' will convince others to contribute more resources to the IMF, boosting its crisis-fighting abilities and improving market sentiment.

But Germany is opposed to such a step.

Chancellor Angela Merkel has said she will not discuss the issue of the ESM/EFSF's ceiling until leaders meet for their next summit in March. In the meantime, financial markets will continue to fret that there may not be sufficient rescue funds available to help the likes of Italy and Spain if they run into renewed debt funding problems.

"There are certainly signals that Germany is willing to consider it and it is rather geared toward March from the German side," a senior euro zone official said.

The sticking point is German public opinion which is tired of bailing out the euro zone's financially less prudent. Instead, Merkel wants to see the EU - except Britain, which has rejected any such move - sign up to the fiscal treaty, including a balanced budget rule written into constitutions. Once that is done, the discussion about a bigger rescue fund can take place.

After nearly three years of crisis, some economists believe the combination of tighter budget rules, a bigger bailout fund and a commitment to broader structural reforms to boost EU productivity could help the region weather the storm.

"The fiscal compact and the ESM will shape a better future," said Carsten Brzeski, a euro zone economist at ING.

"Combined with ongoing austerity measures and structural reforms in peripheral countries, and, of course, with a lot of ECB action, the euro zone could master this stage of the crisis."

Economists say the pivotal act in recent months was the European Central Bank's flooding of the banking sector with cheap three-year money, a measure it will repeat next month.

GREEK DEAL?

While EU leaders are managing to put together pieces of legislation and financial barriers that might help them stave off a repeat of the debt crisis, immediate concerns - especially over Greece and potentially Portugal - remain.

By far the most pressing worry is the seven-month-long negotiation over private sector involvement in the second Greek rescue package. A deal in the coming days may help restore investor confidence, although Greece will still struggle to reduce its debts to 120 percent of GDP by 2020 as planned.

"If there is a deal, the heads of state and government can endorse it, welcome it and say that now it is up to Greece to agree to and deliver on reforms to get the second financing package," the euro zone official said.

Negotiators believe they have until mid-February to strike a deal. Failure to do so by then would likely force Greece to miss a 14.5 billion euro repayment on its debt due in mid-March.

Even if Athens can strike a deal with private bondholders to accept a 50 percent writedown on the nominal value of their bonds, it may still not be enough to close Greece's funding gap.

The IMF has suggested it may be necessary for public sector holders of Greek bonds - including the ECB and national central banks in the euro zone - to write off some of their holdings in order to close the gap.

Such a move would not necessarily involve the ECB or national central banks incurring losses, they would just be expected to forego any profit on the bonds they have bought.

But German ECB board member Joerg Asmussen told Reuters there was no possibility of the ECB taking part in the private-sector restructuring of Greece's debt.

(Reporting By Jan Strupczewski, editing by Mike Peacock)

Source: http://us.rd.yahoo.com/dailynews/rss/eurobiz/*http%3A//news.yahoo.com/s/nm/20120129/bs_nm/us_eu_summit

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Sunday, January 29, 2012

Video: Researchers show how viruses evolve, and in some cases, become deadly

Friday, January 27, 2012

In the current issue of Science, researchers at Michigan State University demonstrate how a new virus evolves, which sheds light on how easy it can be for diseases to gain dangerous mutations.

The scientists showed for the first time how the virus called "Lambda" evolved to find a new way to attack host cells, an innovation that took four mutations to accomplish. This virus infects bacteria, in particular the common E. coli bacterium. Lambda isn't dangerous to humans, but this research demonstrated how viruses evolve complex and potentially deadly new traits, said Justin Meyer, MSU graduate student, who co-authored the paper with Richard Lenski, MSU Hannah Distinguished Professor of Microbiology and Molecular Genetics.

"We were surprised at first to see Lambda evolve this new function, this ability to attack and enter the cell through a new receptor ? and it happened so fast," Meyer said. "But when we re-ran the evolution experiment, we saw the same thing happen over and over."


Researchers at Michigan State University demonstrate how a new virus evolves, shedding light on how easy it can be for diseases to gain dangerous mutations. Credit: Michigan State University/Jeremy Polk, National Science Foundation

This paper follows recent news that scientists in the United States and the Netherlands produced a deadly version of bird flu. Even though bird flu is a mere five mutations away from becoming transmissible between humans, it's highly unlikely the virus could naturally obtain all of the beneficial mutations all at once. However, it might evolve sequentially, gaining benefits one-by-one, if conditions are favorable at each step, he added.

Through research conducted at BEACON, MSU's National Science Foundation Center for the Study of Evolution in Action, Meyer and his colleagues' ability to duplicate the results implied that adaptation by natural selection, or survival of the fittest, had an important role in the virus' evolution.

When the genomes of the adaptable virus were sequenced, they always had four mutations in common. The viruses that didn't evolve the new way of entering cells had some of the four mutations but never all four together, said Meyer, who holds the Barnett Rosenberg Fellowship in MSU's College of Natural Science.

"In other words, natural selection promoted the virus' evolution because the mutations helped them use both their old and new attacks," Meyer said. "The finding raises questions of whether the five bird flu mutations may also have multiple functions, and could they evolve naturally?"

###

National Science Foundation: http://www.nsf.gov

Thanks to National Science Foundation for this article.

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Source: http://www.labspaces.net/117147/Video__Researchers_show_how_viruses_evolve__and_in_some_cases__become_deadly

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Coach honed debating skills of young Newt Gingrich

In this photo taken, Wednesday, Jan. 25, 2012, Chester Gibson, a former professor who ran one of the nation's top-ranked competitive debating programs from the middle of rural Georgia, is photographed in Horton's Bookstore in Carrollton, Ga. As a young college professor running for Congress, Newt Gingrich wanted to sharpen his debating skills. Admirers say the Republican was always a dynamic speaker, but he had flaws. He frowned. He titled his head oddly and fell back repeatedly on the same words. He went for the rhetorical jugular. His supporters worried that TV cameras magnified those delivery problems. Gingrich didn?t need to look far to find help. In the building next to the one where Gingrich taught history at West Georgia College, professor Chester Gibson coached students whose ranks now include a former Georgia governor, high-powered Atlanta attorneys, judges and preachers. He gave Gingrich free help as a new candidate. (AP Photo/David Goldman)

In this photo taken, Wednesday, Jan. 25, 2012, Chester Gibson, a former professor who ran one of the nation's top-ranked competitive debating programs from the middle of rural Georgia, is photographed in Horton's Bookstore in Carrollton, Ga. As a young college professor running for Congress, Newt Gingrich wanted to sharpen his debating skills. Admirers say the Republican was always a dynamic speaker, but he had flaws. He frowned. He titled his head oddly and fell back repeatedly on the same words. He went for the rhetorical jugular. His supporters worried that TV cameras magnified those delivery problems. Gingrich didn?t need to look far to find help. In the building next to the one where Gingrich taught history at West Georgia College, professor Chester Gibson coached students whose ranks now include a former Georgia governor, high-powered Atlanta attorneys, judges and preachers. He gave Gingrich free help as a new candidate. (AP Photo/David Goldman)

In this Sept. 28, 2007 photo provided by Chester Gibson, former House Speaker Newt Gingrich is seen at left with Gibson at a book signing in Horton's Bookstore in Carrollton, Ga. As a young candidate, professor Newt Gingrich had a problem: he was not a great debater. Luckily for Gingrich, Gibson ran one of the nation's top-ranked competitive debating programs from the middle of rural Georgia in the campus building next door. (AP Photo/Courtesy of the Gibson Family)

In this photo taken, Wednesday, Jan. 25, 2012, Chester Gibson, a former professor who ran one of the nation's top-ranked competitive debating programs from the middle of rural Georgia, is photographed in Horton's Bookstore in Carrollton, Ga. As a young college professor running for Congress, Newt Gingrich wanted to sharpen his debating skills. Admirers say the Republican was always a dynamic speaker, but he had flaws. He frowned. He titled his head oddly and fell back repeatedly on the same words. He went for the rhetorical jugular. His supporters worried that TV cameras magnified those delivery problems. Gingrich didn?t need to look far to find help. In the building next to the one where Gingrich taught history at West Georgia College, professor Chester Gibson coached students whose ranks now include a former Georgia governor, high-powered Atlanta attorneys, judges and preachers. He gave Gingrich free help as a new candidate. (AP Photo/David Goldman)

(AP) ? As a young college professor running for Congress, Newt Gingrich wanted to sharpen his debating skills.

Admirers say the Republican was always a dynamic speaker, but with flaws. He frowned. He tilted his head oddly and fell back repeatedly on the same words. He went for the rhetorical jugular. Supporters worried that TV cameras magnified those delivery problems.

Gingrich didn't need to look far for help. In the building next to the one where Gingrich taught history at West Georgia College, professor Chester Gibson coached students whose ranks now include a former Georgia governor, high-powered Atlanta attorneys, judges and preachers. He gave Gingrich free help as a new candidate.

Strong debate performances have kept alive Gingrich's candidacy for the Republican presidential nomination after a bleak period last summer when his staff quit and his campaign fell into debt. After a commanding performance in a pair of South Carolina debates, Gingrich has not performed as strong lately. Former Massachusetts Gov. Mitt Romney was considerably more aggressive in a Florida debate on Thursday, repeatedly putting Gingrich on the defensive.

Now retired, Gibson said he still sees Gingrich's old habits ? good and bad ? in the presidential debates.

"Gingrich is clearly the best debater in the final four," said Gibson, who communicates by email because doctors removed his voice box in 2010 during cancer treatment. "No contest. A Gingrich-Obama debate would be one of the great moments in American political history."

The pair met in 1970 when they started teaching at West Georgia College, now called the University of West Georgia. Gibson coached Gingrich before his first unsuccessful run for the House in 1974 and kept working with him until Gingrich won four years later. Gibson said the coaching continued into Gingrich's early years in office. A Gingrich spokesman did not respond to requests for information for this report.

Gibson, 70, said Gingrich's problem was delivery, not substance.

"He was poised, confident, quick on his feet and well versed in both U.S. and world history," Gibson said. "He read everything that he could get his hands on. His greatest asset was his incredible memory."

In their coaching sessions, Gibson said he filmed Gingrich speaking so he could see his mistakes. The students on Gibson's debate team ? one was Randy Evans, now Gingrich's longtime attorney ? listened and critiqued Gingrich's speeches. They researched the positions of his political opponents and constructed arguments. Gibson traveled with Gingrich to debates so they could practice in the car.

Gibson pushed his students to win.

"He just worked endlessly and worked us very hard because he was as competitive as all get-out," said trial lawyer Paul Weathington, one of Gibson's debaters and a nationally ranked debater in college.

Gibson told Gingrich to work on his body language. When listening intently to another speaker, he tended to frown ? a bad habit that Gibson said the Republican candidate has not fully stopped. In fact, Gingrich recently told reporters that his granddaughter told him to smile more and that she counts his grins during debates.

"I am always pleased when I see a grin because I know that he is ready to launch into a great answer to the question," Gibson said.

Years ago, Gibson encouraged Gingrich to tone down grandiose statements, saying they distract the audience from the message.

Then, as now, Gingrich would occasionally cock his head oddly to the right, Gibson said. When he latched onto a word, he'd use it repeatedly.

"Listen to the number of times that he uses the word 'frankly,'" Gibson said. "You will lose count."

Gingrich understands how to exploit TV debates and has avoided any major gaffes, said Mitchell McKinney, a communications professor at the University of Missouri who studies presidential debates. When his campaign was lagging, Gingrich baited the front-runners to engage him during debates, which helped him get airtime. He also picks messages that are sure to be replayed on TV. It adds up to free publicity.

"These moments get captured and played over and over," McKinney said.

One such moment came last week in the South Carolina. CNN debate moderator John King started the broadcast by asking Gingrich to respond to his second ex-wife's accusation that he asked her for an open marriage.

"I think the destructive, vicious, negative nature of much of the news media makes it harder to govern this country, harder to attract decent people to run for public office," said Gingrich, on his way to gaining a standing ovation from the audience. "And I am appalled that you would begin a presidential debate on a topic like that."

He won the primary two days later.

___

Follow Ray Henry on Twitter: http://www.twitter.com/rhenryAP

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-01-27-Gingrich-Debate%20Coach/id-603677e37e6947099d70bdcdc2b2ec48

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Saturday, January 28, 2012

Discovery of new vaccine approach for treatment of cancer

Discovery of new vaccine approach for treatment of cancer [ Back to EurekAlert! ] Public release date: 27-Jan-2012
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Contact: Caoimhe Ni Lochlainn
communications@tcd.ie
353-189-62310
Trinity College Dublin

The findings were published online in Cancer Research

Scientists in Trinity College Dublin, Ireland, have developed a new vaccine to treat cancer at the pre-clinical level. The research team led by Professor Kingston Mills, Professor of Experimental Immunology at Trinity College Dublin discovered a new approach for treating the disease based on manipulating the immune response to malignant tumours. The discovery has been patented and there are plans to develop the vaccine for clinical use for cancer patients.

The first cancer vaccine Sipuleucel-T (Provenge) was licensed last year for use in prostate cancer patients unresponsive to hormone treatment. Unfortunately, this cell based vaccine only improves patient survival by an average of 4.1 months. Vaccines for infectious diseases are highly effective at generating immune responses that prevent infection with bacteria or viruses. The immune system can also protect us against tumours and in theory a vaccine approach should be effective against cancer. In practice this has proven very difficult because unlike infectious diseases, tumours are derived from normal human cells, and not made up of foreign substances or antigens capable of triggering an immune response. The tumours instead produce molecules that suppress the efficacy of the immune system. They generate regulatory cells that inhibit the immune response that could potentially clear the tumours.

Professor Mills' group has developed a novel vaccine and immunotherapeutic approach that can overcome these obstacles and has the potential to significantly improve on existing technologies. The therapy is based on a combination of molecules that manipulates the immune response to curb the regulatory arm while enhancing the protective arm, allowing the induction of specialist white blood cell called killer T cells to target and eliminate the tumours. The new vaccine approach was found to be highly effective at pre-clinical stage in treating a range of cancers in murine models.

The findings were published in December online in Cancer Research, the leading journal of The American Association of Cancer Research. The research was performed by a Senior Postdoctoral Fellow Dr Neil Marshall, at Trinity College Dublin, with the help of two PhD students, Anna-Maria Corcoran and Karen Galvin and was funded by a Science Foundation Ireland Principal Investigator award to Professor Mills. The discoveries have been patent protected and Professor Mills has plans to translate them to the clinic via a TCD Campus Company, TriMod Therapeutics that he co-founded with Dr Jeremy Skillington.

###

For a copy of the Cancer Research article click on: http://cancerres.aacrjournals.org/content/early/2011/12/09/0008-5472.CAN-11-0307.abstract


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Discovery of new vaccine approach for treatment of cancer [ Back to EurekAlert! ] Public release date: 27-Jan-2012
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Contact: Caoimhe Ni Lochlainn
communications@tcd.ie
353-189-62310
Trinity College Dublin

The findings were published online in Cancer Research

Scientists in Trinity College Dublin, Ireland, have developed a new vaccine to treat cancer at the pre-clinical level. The research team led by Professor Kingston Mills, Professor of Experimental Immunology at Trinity College Dublin discovered a new approach for treating the disease based on manipulating the immune response to malignant tumours. The discovery has been patented and there are plans to develop the vaccine for clinical use for cancer patients.

The first cancer vaccine Sipuleucel-T (Provenge) was licensed last year for use in prostate cancer patients unresponsive to hormone treatment. Unfortunately, this cell based vaccine only improves patient survival by an average of 4.1 months. Vaccines for infectious diseases are highly effective at generating immune responses that prevent infection with bacteria or viruses. The immune system can also protect us against tumours and in theory a vaccine approach should be effective against cancer. In practice this has proven very difficult because unlike infectious diseases, tumours are derived from normal human cells, and not made up of foreign substances or antigens capable of triggering an immune response. The tumours instead produce molecules that suppress the efficacy of the immune system. They generate regulatory cells that inhibit the immune response that could potentially clear the tumours.

Professor Mills' group has developed a novel vaccine and immunotherapeutic approach that can overcome these obstacles and has the potential to significantly improve on existing technologies. The therapy is based on a combination of molecules that manipulates the immune response to curb the regulatory arm while enhancing the protective arm, allowing the induction of specialist white blood cell called killer T cells to target and eliminate the tumours. The new vaccine approach was found to be highly effective at pre-clinical stage in treating a range of cancers in murine models.

The findings were published in December online in Cancer Research, the leading journal of The American Association of Cancer Research. The research was performed by a Senior Postdoctoral Fellow Dr Neil Marshall, at Trinity College Dublin, with the help of two PhD students, Anna-Maria Corcoran and Karen Galvin and was funded by a Science Foundation Ireland Principal Investigator award to Professor Mills. The discoveries have been patent protected and Professor Mills has plans to translate them to the clinic via a TCD Campus Company, TriMod Therapeutics that he co-founded with Dr Jeremy Skillington.

###

For a copy of the Cancer Research article click on: http://cancerres.aacrjournals.org/content/early/2011/12/09/0008-5472.CAN-11-0307.abstract


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-01/tcd-don012712.php

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Friday, January 27, 2012

Newt Gingrich on Mitt Romney: He Thinks We're All Stupid!


The Florida Republican primary is less than a week away and the gloves are off.

Having been whomped in South Carolina, Mitt Romney came out firing in Monday night's Florida debate and has kept up the pressure on his GOP rival all week.

New pro-Romney ads are calling Gingrich a liar who's exaggerating loose ties to Ronald Reagan and drops names instead of touting his own policy credentials.

Newt lashed out at Mitt today for questioning his conservative values. Watch:

"This is the man who stood up the other night to question my credentials as a Reaganite? This is the kind of gall they have to think we are so stupid, and we are so timid," Gingrich said at an outdoor campaign event in Orlando, Florida.

Newt has slipped a bit in recent polls since his demonstrative win. Can he shift the momentum back his way when the candidates debate again tonight?

Source: http://www.thehollywoodgossip.com/2012/01/newt-gingrich-on-mitt-romney-he-thinks-were-all-stupid/

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Conservative India unlikely hotspot on gay tourism map (Reuters)

NEW DELHI (Reuters) ? When Thomas Roth first visited India, he was often asked about his wife and children -- questions he would try to evade.

That was thirty years ago, when homosexuality was a criminal offence in India and for many the term "gay" only meant "happy."

Roth is again planning a trip to India, this time with his partner, and hopes the visit will coincide with the annual Queer Pride parade in New Delhi.

"(Earlier) like most gays in India at that time, I was basically invisible," said Roth, who runs a lesbian, gay, bisexual and transgender (LGBT) community market research firm in San Francisco.

"Now, with emerging Gay Pride events, film festivals, parties, etc. gay visitors can have it all," he added, in an email interview.

Since homosexuality was decriminalized in India in 2009, an increasing number of LGBT tourists are viewing India as a holiday destination.

A survey conducted by Roth's firm in the United States last year ranked India as the second most desired cultural or adventure destination, just behind Thailand.

Changing mindsets have created business possibilities for travel operators, who are now portraying India as an emerging gay-friendly destination.

Four years ago, there wasn't a single gay tourism company in India. The International Gay & Lesbian Travel Association (IGLTA) now lists seven gay-friendly or exclusively LGBT travel agents in India.

"Word about India has travelled far and wide through the Internet," said Sanjay Malhotra, owner of Indjapink, which calls itself India's first gay travel boutique. He started with 20 clients but now has more than 100.

"Five years ago, the gay community had so many apprehensions travelling to India," he added. "Now, they look at the option of travelling to India without acting heterosexual."

Tours cover everything from honeymoon packages and candle-lit dinners to wildlife safaris and spiritual retreats. An opportunity to interact with the local gay community is the icing on the cake.

Malhotra has even conducted weddings with traditional Hindu rites for two couples.

Not that it is impossible for LGBT tourists to experience India without a travel agent. When economist Qing Wu visited North India with his partner, he said he "never felt uncomfortable" as a couple.

"In India, it is fairly common to see boys holding hands," said Wu, who lives in San Francisco, via email. "I personally feel pretty safe."

The special packages provided by LGBT tour companies in India also ensure clients can be completely uninhibited during their visit. The entire staff, if not gay, is gay-friendly.

"It is my duty that no taxi driver or guide says anything offensive," said Abhinav Goel, owner of Out Journeys in New Delhi.

Typically, these packages are mid-range to luxury and most of the clientele comes from the United States and Australia. A majority of these agencies still cater to men, though the survey by Roth's firm showed India was the most desired destination among lesbians in North America.

"We cannot truly call ourselves LGBT till we do something about the 'L' part of it," said Goel, who is planning on starting a group package for lesbians.

India is still way behind places such as Hong Kong and Thailand, which have openly gay communities and gay-friendly infrastructure.

Operators say it would be hard for India to compete with these destinations without visible government support.

"They just have to make the statement that Incredible India supports gay travelers," said Goel. "That small and simple statement could really open the doors."

(Editing by John Chalmers and Elaine Lies)

Source: http://us.rd.yahoo.com/dailynews/rss/parenting/*http%3A//news.yahoo.com/s/nm/20120126/lf_nm_life/us_india_gay_tourism

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Thursday, January 26, 2012

Tilda Swinton isn't upset about Oscar snub (AP)

NEW YORK ? Tilda Swinton wasn't nominated for an Academy Award for her role in "We Need to Talk About Kevin," but she wasn't sad after hearing the news.

"I wasn't disappointed. I didn't know for hours, but someone was telling me apparently everyone else was disappointed. I had very low expectations, so perhaps my expectations were a bit lower than everybody else," the 51-year-old actress said Tuesday at an event celebrating "Here," a short film starring supermodel Agyness Deyn that Swinton conceived for Starwood Hotels & Resorts Worldwide Inc.'s Luxury Collection brand.

"I am a good gambler, so I knew we were not really going to be in there. I am amazed that our little film got as far as it did," she said.

Swinton took home an Oscar in 2008 for best supporting actress for "Michael Clayton."

This time, she not only starred in "We Need to Talk about Kevin," but also served as an executive producer. Swinton was nominated for a Golden Globe for her role in the film, and she said being nominated for any major award was a win for the movie.

"This is a film that was put out by a tiny distributor who doesn't have the money to put ads on the sides of buses or television ads or have a whole page in a newspaper, so for us, nominations and prizes are a big deal because by that way, people hear about our film."

Swinton lost to Meryl Streep at the Golden Globes, but she holds no hard feelings.

Who is going to win best actress at the Oscars? Swinton replied: "Meryl Streep is going to win it for sure." When later asked if she always keeps a sense of humor about awards, Swinton smiled back and said, "Well, what is the alternative?"

___

Online:

http://www.theluxurycollection.com/thefilmhere

Source: http://us.rd.yahoo.com/dailynews/rss/entertainment/*http%3A//news.yahoo.com/s/ap/20120125/ap_en_ot/us_oscar_nominations_swinton

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Video: Romney pays less than 14 percent in taxes

Presidential candidate Mitt Romney released his tax returns, revealing that nearly all of his income is from investments. NBC?s Andrea Mitchell reports.

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Source: http://video.msnbc.msn.com/nightly-news/46122803/

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Wednesday, January 25, 2012

Romney paid $3M in federal income tax in 2010

Republican presidential candidate, former Massachusetts Gov. Mitt Romney gestures during a Republican presidential debate Monday Jan. 23, 2012, at the University of South Florida in Tampa, Fla. (AP Photo/Paul Sancya)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney gestures during a Republican presidential debate Monday Jan. 23, 2012, at the University of South Florida in Tampa, Fla. (AP Photo/Paul Sancya)

(AP) ? Republican presidential candidate Mitt Romney paid about $3 million in federal income taxes in 2010, having earned more than seven times that from his investments. Those earnings, $21.7 million, put him among the wealthiest of American taxpayers.

At the same time, Romney gave nearly $3 million to charity ? about half of that amount to the Mormon Church ? which helped lower his effective tax rate to a modest 14 percent, according to records his campaign released early Tuesday.

For 2011, he'll pay about $3.2 million with an effective tax rate of about 15.4 percent, the campaign said. Those returns haven't yet been filed yet with the Internal Revenue Service.

The former Massachusetts governor had been under pressure in recent weeks to release his tax returns, his GOP opponents casting him as a wealthy businessman who slashed jobs in the private sector. Rival Newt Gingrich made public his returns on Saturday, showing he paid almost $1 million in income taxes ? a tax rate of about 31 percent.

Romney's campaign confirmed the details of his tax information after several news organizations saw a preview of the documents. He had said he planned to release his returns in full Tuesday morning, and campaign officials would be prepared to discuss them in detail with reporters.

"You'll see my income, how much taxes I've paid, how much I've paid to charity," Romney said during Monday night's debate in Tampa. "I pay all the taxes that are legally required and not a dollar more. I don't think you want someone as the candidate for president who pays more taxes than he owes."

Romney's 2010 returns show the candidate is among the top 1 percent of taxpayers. The returns showed about $4.5 million in itemized deductions, including $1.5 million to the Church of Jesus Christ of Latter-Day Saints.

Before the tax records were released, Romney's old investments in two government-backed housing lenders stirred up new questions at the same time his campaign targeted Gingrich for his work for Freddie Mac.

Gingrich earned $1.6 million in consulting fees from Freddie Mac. Romney has as much as $500,000 invested in the U.S.-backed lender and its sister entity, Fannie Mae.

The fight over releasing the tax information highlighted an argument that Democrats are already starting to use against Romney ? that he is out-of-touch with normal Americans. And it probably hurt him in the South Carolina primary, where he lost by 12 percentage points to Gingrich after spending several days resisting releasing the returns.

On Monday, Romney would not answer questions from debate moderator Brian Williams about just what pieces of his tax returns could cause political headaches. But they will shine the spotlight on a fortune estimated at between $190 million and $250 million, and could raise questions about where he keeps his money and how he earns it.

For example, Romney keeps some of his personal fortune in investments that are domiciled in the Cayman Islands, where many international investors shelter their income from American taxes. Romney aides say he doesn't use the funds to avoid or put off paying the appropriate taxes.

The returns could also reveal more details about his annual take as founder of the Bain Capital private equity firm.

But it's clear that Romney's campaign is bracing for an onslaught of criticism of his personal fortune. His wife, Ann, has started talking about the returns during campaign appearances. She told supporters at a Florida rally Sunday: "I want to remind you where we know our riches are. Our riches are with our families."

Most of Romney's vast fortune is held in a blind trust that he doesn't control. A portion is held in a retirement account.

___

Gillum reported from Washington.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-01-24-Romney-Taxes/id-63dfcbe5e50e4e09a8557034ad67bf33

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2 more cruise bodies found, oil pumping to begin

Italian Navy scuba divers return after working on the grounded cruise ship Costa Concordia off the Tuscan island of Giglio, Italy, Monday, Jan. 23, 2012. Italian officials were clearing hurdles Monday to begin pumping some half a million gallons of fuel from the capsized Costa Concordia that threaten an environmental catastrophe, as divers continued the search for 19 people known missing. (AP Photo/Pier Paolo Cito)

Italian Navy scuba divers return after working on the grounded cruise ship Costa Concordia off the Tuscan island of Giglio, Italy, Monday, Jan. 23, 2012. Italian officials were clearing hurdles Monday to begin pumping some half a million gallons of fuel from the capsized Costa Concordia that threaten an environmental catastrophe, as divers continued the search for 19 people known missing. (AP Photo/Pier Paolo Cito)

Oil recovery technicians work in the harbor of the Tuscan island of Giglio, Italy, where the cruise ship Costa Concordia run aground, Monday, Jan. 23, 2012. Italian officials were clearing hurdles Monday to begin pumping some half a million gallons of fuel from the capsized Costa Concordia that threaten an environmental catastrophe, as divers continued the search for 19 people known missing. (AP Photo/Pier Paolo Cito)

US John Heil, son of Barbara and Gerald Heil, both missing in the grounding of the cruise ship Costa Concordia stands in the harbor of the Tuscan island of Giglio, Italy, Monday, Jan. 23, 2012. Italian officials were clearing hurdles Monday to begin pumping some half a million gallons of fuel from the capsized Costa Concordia that threaten an environmental catastrophe, as divers continued the search for 19 people known missing. (AP Photo/Pier Paolo Cito)

The cruise ship Costa Concordia lies on its side off the Tuscan island of Giglio, Italy, Sunday, Jan. 22, 2012. Rescuers on Sunday resumed searching the above-water section of the capsized Costa Concordia cruise liner, but choppy seas kept divers from exploring the submerged part, where officials have said there could be bodies. Civil protection officials said that until the waves slack off, divers would not swim into the submerged part of the vessel just off the port of Giglio, a tiny Island off the Tuscan coast. (AP Photo/Pier Paolo Cito)

The cruise ship Costa Concordia lies on its side off the Tuscan island of Giglio, Italy, Sunday, Jan. 22, 2012. Rescuers on Sunday resumed searching the above-water section of the capsized Costa Concordia cruise liner, but choppy seas kept divers from exploring the submerged part, where officials have said there could be bodies. Civil protection officials said that until the waves slack off, divers would not swim into the submerged part of the vessel just off the port of Giglio, a tiny Island off the Tuscan coast. (AP Photo/Pier Paolo Cito)

(AP) ? Salvage experts can begin pumping fuel from a capsized cruise ship as early as Tuesday to avert a possible environmental catastrophe and the ship is stable enough that search efforts for the missing can continue, Italian officials said.

The decision to carry out both operations in tandem was made after instrument readings determined that the Costa Concordia was not at risk of sliding into deeper waters, Franco Gabrielli, chief of the national civil protection agency, told reporters Monday on the island of Giglio.

"The ship is stable. ... There is no problem or danger that it is about to drop onto much lower seabed," Gabrielli said.

The Concordia rammed a reef Jan. 13 on the tiny Tuscan island and capsized a few hours later just outside Giglio's port as it carried 4,200 passengers and crew on a Mediterranean cruise.

Taking advantage of calm seas, divers on Monday found the bodies of two women near the ship's Internet cafe, raising to 15 the number of confirmed dead.

There are 17 people still unaccounted for, but Gabrielli has said an unregistered Hungarian woman might have been aboard ship. The woman's relatives have told Italian authorities they haven't heard from her since she called them to say she was aboard the ship.

The ship's Italian captain, Francesco Schettino is under house arrest near Naples as prosecutor's investigate him for suspected manslaughter, causing a shipwreck and abandoning his vessel while some passengers and crew were still aboard. He has insisted that he was coordinating rescue operations from a lifeboat and then from shore.

Costa Crociere SpA has distanced itself from the captain, contending that he made an unauthorized deviation from the programmed route. Schettino has reportedly told investigators that Costa officials had requested that he sail close to Giglio in a publicity move.

Schettino's lawyer, Bruno Leporatti, told reporters Monday that tests on urine and hair samples found that his client had not been under the influence of alcohol or drugs before the crash. Prosecutors could not confirm the report, since they cannot speak about the investigation while it is still under way.

Despite earlier fears, officials said the crippled cruise ship, with a 70-meter (230-foot) long gash in its hull, is not expected to roll off its rocky seabed perch and be completely swallowed by the sea.

An Italian geologist, on Giglio to monitor the Concordia, told Sky TG24 Monday the ship was barely moving.

"It is moving at the rate of about one or two millimeters an hour," said Nicola Casagli, adding the ship has moved up to 3mm an hour when tides come in or out. "The ship responds to the tides."

The sea has been calm for several days but he said waves were expected to grow larger in the next few days.

In all, seven bodies await identification, but Gabrielli said officials have DNA from the relatives of all of the missing passengers and are working to confirm names and nationalities. He said the search would continue "as long as it is possible to inspect whatever can be inspected."

Meanwhile, Italian Admiral Ilarione dell'Anna said the fuel removal could begin as early as Tuesday, addressing growing concern among residents and environmentalists that the heavy, tar-like fuel could leak from the ship's 17 double-bottomed tanks.

"They should start the oil drainage operations on the ship. At this point those who died will not come back to life. Even if they pull them out later, unfortunately it won't make a difference," Andrea Ginanneschi, a resident of Giglio, told The Associated Press.

Dell'Anna predicted it would take 28 days to remove all of the fuel, without any interruptions. Officials said the first tank to be emptied will be one above the waterline.

Eight kilometers (five miles) of oil barriers, including absorbent ones, have been laid in the area to protect marine life and the coast in the pristine waters off Giglio, which are prime fishing grounds and a protected area for dolphins and whales.

Recovery experts from the Dutch salvage company Smit have previously said they will create holes in the top and the bottom of each tank, heating the fuel so it flows more easily and pumping from the top while forcing air in from the bottom. For the underwater tanks, sea water will be used to displace the fuel, which becomes thick and gooey when cooled.

Already, some diesel and lubricants have leaked into the water near the ship, probably from machinery on board. Officials have characterized the contamination as superficial.

"Smit has been ready for a week to begin pumping fuel from the tanks, awaiting only the go- ahead," said a company statement. "For this purpose, SMIT has mobilized an oil tanker with emergency response equipment including sweeping arms, booms and a skimmer."

It said the vessel arrived on Monday.

The company also said Italian authorities have indicated it can begin the removal once a second absorbent boom is in place around the ship. The booms are used "to reduce the possibility of polluting shorelines and to help make recovery easier."

Besides 2,200 metric tons of heavier fuel, there also are 185 metric tons of diesel and lubricants on board in addition to chemicals including cleaning products and chlorine.

__

Barry reported from Milan. Andrea Foa reported from Giglio.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-01-23-EU-Italy-Cruise-Aground/id-c1669ddba0454abd937c15851d37db0c

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Tuesday, January 24, 2012

The Rise of Nimble Medicine

Innovator's Prescription - New Wave of Disruptive Models in HealthcareIn the New Yorker, Dr. Atul Gawande outlined how, at the turn of the 20th century, more than forty per cent of household income went to paying for food and food production consumed nearly half the workforce. Starting in Texas, a wide array of new methods of food production were tested. Long story short, food now accounts for 8% of household budgets and 2% of the workforce. As a wide array of small innovations ultimately led to the transformation of farming, so too is a rapidly building wave of innovative new care and payment models leading to similar breakthroughs in healthcare. I call this Nimble Medicine.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/dqNFIjHNnh4/

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Kazakhstan vote fails key democracy test, say officials (+video)

The oil-rich former Soviet republic of Kazakhstan has yet to hold an election that Western observers agree is fair, despite 20 years of democracy.

International election observers have slammed Sunday's snap parliamentary elections in Kazakhstan?as failing to meet the fundamental principles of democracy.

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That verdict could be a painful blow to Kazakh President Nursultan Nazarbayev, who moved the voting forward after oil worker protests shook a city in western Kazakhstan. The elections were a possible effort to improve the country?s international image and avoid an "Arab Spring" type uprising in the oil-rich central Asian republic.

Mr. Nazarbayev hailed the voting as "unprecedented in terms of transparency, openness, and honesty." Although he allowed two opposition parties to gain entry to the country's parliament (Mazhilis), which had formerly been completely dominated by members of the ruling Nur Otan Party, as well as a few independents he selected.

"If Kazakhstan authorities are serious about their stated goals of increasing the number of parties in parliament, then they should have allowed more genuine opposition parties to participate in this election," OSCE Parliamentary Assembly President Joao Soares told a press conference in the Kazakh capital of Astana Monday.

According to final election results, Nur Otan won 81 percent of the vote, which will give it 83 deputies in the 107-seat lower house. The pro-government Ak Zhol Party (once led by Nazarbayev?s daughter) won 7.5 percent (8 seats), while the Communist Peoples Party gained by 7.2 percent (seven seats). Other parties failed to clear the 7 percent threshold.

Most opposition parties were barred from participating in the elections, and several candidates who were objectionable to authorities were stricken from the ballot, according to the Organization for Security and Cooperation in Europe (OSCE), which fielded 400 observers.

Opposition party leaders said they had evidence of ballot stuffing, multiple voting, and coercion of voters, which they said they would post online.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/QPbVC6xH5vE/Kazakhstan-vote-fails-key-democracy-test-say-officials-video

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Monday, January 23, 2012

Prison Planet.com ? Cancer Drugs Make Tumors More Aggressive ...

Prisonplanet.com
January 22, 2012

Guest Mike Adams of NaturalNews.com discusses breakthrough research that suggests chemotherapy can be more dangerous than helpful, as findings show it can multiply the chances of tumors and the presence of cancer in patients.


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Source: http://www.prisonplanet.com/cancer-drugs-make-tumors-more-aggressive-infowars-nightly-news.html

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Obama's State of the Union: Jobs, re-election time (AP)

WASHINGTON ? Vilified by the Republicans who want his job, President Barack Obama will stand before the nation Tuesday night determined to frame the election-year debate on his terms, using his State of the Union address to outline a lasting economic recovery that will "work for everyone, not just a wealthy few."

As his most powerful chance to make a case for a second term, the prime-time speech carries enormous political stakes for the Democratic incumbent who presides over a country divided about his performance and pessimistic about the nation's direction. He will try to offer a stark contrast with his opponents by offering a vision of fairness and opportunity for everyone.

In a preview Saturday, Obama said in a video to supporters that the speech will be an economic blueprint built around manufacturing, energy, education and American values.

He is expected to announce ideas to make college more affordable and to address the housing crisis still hampering the economy three years into his term, people familiar with the speech said. Obama will also propose fresh ideas to ensure that the wealthy pay more in taxes, reiterating what he considers a matter of basic fairness, the officials said.

His policy proposals will be less important than what Obama hopes they all add up to: a narrative of renewed American security with him at the center, leading the fight.

"We can go in two directions," Obama said in the campaign video. "One is toward less opportunity and less fairness. Or we can fight for where I think we need to go: building an economy that works for everyone, not just a wealthy few."

That line of argument is intended to tap directly into concerns of voters who think America has become a nation of income inequality, with rules rigged to help the rich. The degree to which Obama or his eventual Republican opponent can better connect with millions of hurting Americans is expected to determine November's presidential election.

Obama released his video hours ahead of the South Carolina primary, where Republican candidates fought in the latest fierce contest to become his general election rival.

The White House knows Obama is about to get his own stage to outline a re-election vision, but carefully. The speech is supposed to an American moment, not a campaign event.

Obama didn't mention national security or foreign policy in his preview, and he is not expected to break ground on either one in his speech.

He will focus on the economy and is expected to promote unfinished parts of his jobs plan, including the extension of a payroll tax cut that is soon to expire.

Whatever Obama proposes is likely to face long odds in a deeply divided Congress.

More people than not disapprove of Obama's handling of the economy, and he is showing real vulnerability among the independent voters who could swing the election. Yet he will step into the moment just as the economy is showing life. The unemployment rate is still at a troubling 8.5 percent, but at its lowest rate in nearly three years. Consumer confidence is up.

By giving a sneak peek to millions of supporters on his email list, Obama played to his Democratic base and sought to generate an even larger audience for Tuesday's address. He is unlikely to getter a bigger stage all year.

More people watched last year's State of the Union than tuned in to see Obama accept the Democratic presidential nomination in Denver in 2008.

The foundation of Obama's speech is the one he gave in Kansas last month, when he declared that the middle class was at a make-or-break moment and he railed against "you're on your own" economics of the Republican Party. His theme then was about a government that ensures people get a fair shot to succeed.

The State of the Union will be the details to back that up.

But even so, the speech will still be a framework ? part governing, part inspiration.

The details will be rolled out in full over the next several weeks, as part of Obama's next budget proposal and during his travels, which will allow him more media coverage.

On national security, Obama will ask the nation to reflect with him on a momentous year of change, including the end of the war in Iraq, the killing of al-Qaida terrorist leader Osama bin Laden and the Arab Spring protests, with people clamoring for freedom. He is expected to note the troubles posed by Iran and Syria without offering new positions about them.

Despite low expectations for legislation this year, Obama will offer short-term ideas that would require action from Congress. For now, the main looming to-do item is an extension of a payroll tax cut and unemployment benefits, both due to expire by March.

His travel schedule following his speech, to politically important regions, offers clues to the policies he was expected to unveil.

Both Phoenix and Las Vegas have been hard hit by foreclosures. Denver is where Obama outlined ways of helping college students deal with school loan debt. Cedar Rapids, Iowa, and Detroit are home to a number of manufacturers. And Michigan was a major beneficiary of the president's decision to intervene to rescue the American auto industry.

Republican leaders in Congress say Obama has made the chances of cooperation even dimmer just over the last several days. He enraged Republicans by installing a consumer watchdog chief by going around the Senate, which had blocked him, and then rejected a major oil pipeline project the GOP has embraced.

Obama is likely, once again, to offer ways in which a broken Washington must work together. Yet that theme seems but a dream given the gridlock he has been unable to change.

The address remains an old-fashioned moment of national attention; 43 million people watched it on TV last year. The White House website will offer a live stream of the speech, promising extra wrinkles for people who watch it there, and then invite people to send in questions to administration officials through social media such as Twitter and Facebook.

Obama's campaign is also organizing and promoting parties around the nation for people to watch the speech.

__

AP deputy director of polling Jennifer Agiesta and Associated Press writer Ken Thomas contributed to this report.

__

Online:

White House: http://www.whitehouse.gov

___

Follow Ben Feller at http://twitter.com/BenFellerDC

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20120122/ap_on_bi_ge/us_obama_state_of_the_union

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